Cancer cell before
Cancer cell after

ARF6 Inhibitors

ARF6 plays a critical role in pathologic protein trafficking in conditions as seemingly diverse as acute lung injury and melanoma.  A6 Pharmaceuticals has identified proprietary small molecule inhibitors of ARF6. Using these compounds, we have demonstrated efficacy in in vivo models of disease including uveal melanoma, malignant sarcoma, acute lung injury/acute respiratory distress syndrome, multi-drug resistant gram negative bacterial pneumonia, and diabetic retinopathy.

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